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The study found that serum B12 levels were comparable, and in some cases higher, among those using the sublingual supplement (1)

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Harmon DE, Ruiz C, Bradford PA

Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor B: differential regulation of collagenase 1 and collagenase 3

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However, caution is advised when combining with other metabolic supplements or stimulants, as additive effects may occur